Chemistry Space
Chairs: | Chris Lipinski, Melior Discovery (Waterford, US) |
| John Harris, cjh consultants, Pharmaceutical R&D (Eynsford, UK) |
Session Summary:
- General aspects of chemical space:
This session is intended to pick up on the growing interest in relating (physico)chemical properties to both ends of the drug development spectrum, that is, how properties relate to ultimate develop-ability on the one hand, and how the properties of very small sub-fragments of developable drugs relate to the derived leads and development candidates. - Fragment-based drug discovery (FBDD):
As fragment screening and subsequent follow-up has become such an important alternative to classic high-throughput or focused library screening, which cover, arguably, less chemical space, this session picks up firstly on a review of the associated technologies and then follows up with two real-life stories of FBDD - Multi-target drug discovery (MTDD):
Once again, this session picks up on an important theme that has been the subject of previous isolated talks at MipTec. In view of the major growth of interest in this field, we have included a full session of the topic at Miptec 2012, with a review talk to start followed by two case-studies of successful rational MTDD