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Natural Products and Synthetic Biology

Natural Products and Synthetic Biology


Thursday, 26 September 2013

Room: 2
Organizers:Charles MooreNovartis Pharma AG (Basel, CH)
 Tim SchuhmannNovartis Pharma AG (Basel, CH)
 Yaakov Benenson ETH Zurich (Basel, CH)

Forum Description
Natural Products and Synthetic biology are two areas of research that are finding increasing areas of overlap. Genetic engineering has been applied to natural products research almost since its inception in the early 1970’s, however, genetic engineering itself is undergoing a revolution catalyzed by the widespread application of next generation sequencing technologies, improvements in DNA synthesis technologies and from progress made in the rapidly developing field of synthetic biology. The goal of this session is to survey research from laboratories working at the nexus of these two fields with an emphasis placed on discovering how recent advances in the field of synthetic biology can help drive natural products research to facilitate drug discovery.


Thursday, 26 September 2013

Welcome Remarks

Production of Myxobacterial Metabolites based on Synthetic DNA
S. Wenzel*
Saarland University (Saarbrücken, DE)

Genome Mining 2.0: Development and application of bioinformatic tools to assess the biosynthetic potential of microorganisms
T. Weber*
Eberhard Karls University (Tübingen, DE)

Genome-based Discovery of Small-Molecule Biologics
G.L. Verdine*
Harvard University (Cambridge, US)

Rapid and Reliable Gene Construction with gBlocks(tm) Gene Fragments and Gibson Assembly (tm) Method
M. Cannieux*
Integrated DNA Technologies (Coralville, US)

Genome mining and heterologous expression for natural products discovery in actinomycetes
J.P. Gomez-Escribano*
John Innes Centre (Norwich, UK)


High throughput tools to support biological engineering
S. Panke*
ETH Zurich (Basel, CH)

Directed Evolution of PNPase for Nelarabine production
J.B. Brown*
GlaxoSmithKline (Stevenage, UK)

miRNA confer phenotypic robustness to gene networks: A synthetic biology approach
C. Fracassi*
TIGEM (Naples, IT)

RNA-guided genome editing using the CRISPR-Cas system
M. Jinek*
University of Zurich (Zurich, CH)

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